Class Switch Recombination ·
IgM → IgG · AID · NHEJ
un
seel
.com · IGH locus · switch regions · deletional recombination
Isotype
IgM
DNA deleted
0 kb
State
—
V(D)J exon (antigen specificity)
Switch regions Sμ · Sγ
AID + double-strand breaks
New constant gene Cγ (IgG)
NHEJ join · excised switch circle
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Un
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.com · Class Switch Recombination
Un
seel
.com · Antibody Class Switch Recombination