Germinal Center Reaction ·
Dark Zone ⇄ Light Zone Cycling
un
seel
.com · SHM · AID · Tfh selection · affinity maturation
Cycle
0
Affinity K
D
10⁻⁶ M
phase
—
Centroblast / B cell
AID / somatic hypermutation
FDC antigen · BCR capture
Tfh help (CD40L / IL-21)
Apoptosis (failed selection)
▶ Play
←
→
🔇 Unmute
Reset
Un
seel
.com · Germinal Center Reaction