Thiamine Pyrophosphate ·
The Acidic-Carbon Cofactor
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.com · thiazolium ylide · C2 electron sink · pyruvate → CO₂
Turnover
~10³/s
CO₂ released
0
Step
—
Thiazolium ring (N⁺ / S)
Aminopyrimidine + PPi tail
Pyruvate substrate
C2 ylide / hydroxyethyl-TPP
CO₂ leaving group
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.com · Thiamine Pyrophosphate (TPP)