Concerted Metalation-Deprotonation ·
How a Carboxylate Cleaves a C–H Bond
un
seel
.com · Pd(II) · pivalate · C–H activation
Pd state
Pd(II)
internal base
⁻O₂CtBu
KIE k_H/k_D
—
step
—
Pd(II) metal
carboxylate O
the proton (H)
aryl C–H (C₆F₅)
▶ Play
←
→
🔇 Unmute
Reset
Un
seel
.com · Concerted Metalation-Deprotonation
Un
seel
.com · Concerted Metalation-Deprotonation — Concepts