Fischer Indole Synthesis ·
[3,3]-Shift Builds the Ring
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.com · ArNHNH₂ + ketone —H⁺→ indole + NH₃ · Fischer 1883
Stage
condensation
N–N bond
intact
Step
reagents assembled
Aromatic ring (from Ar)
Nitrogen (N1 & terminal N)
Ketone carbons (→ C2, C3)
New C–C bond ([3,3])
Leaving NH₃ / H⁺
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.com · Fischer Indole Synthesis