Hofmann Rearrangement ·
Amide → Amine, −1 Carbon
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seel
.com · R-CONH₂ + Br₂/NaOH → R-NH₂ + CO₂ · Hofmann 1881
N state
amide N
Carbons in chain
n+1
Stage
primary amide ready
Migrating group R (carbon)
Carbonyl / CO₂ carbon
Nitrogen
Oxygen
Bromine (leaves)
Hydrogen
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