Kolbe-Schmitt ·
Phenoxide + CO₂ → Salicylic Acid
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.com · sodium → ortho · the aspirin route
Ring state
phenoxide
C-C bonds made
0
Stage
reagents assembled
Aromatic ring C
Oxygen (phenoxide / C=O)
Na⁺ template cation
CO₂ carbon (electrophile)
New carboxylate -COO⁻
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