Low-Barrier Hydrogen Bonds · The Short, Strong Bond That Supercharges Enzymes
unseel.com · proton transfer · pKₐ matching · enzyme catalysis
O···O 2.8 Å
barrier high
¹H δ 10 ppm
step
donor / acceptor O
shared proton H⁺
proton-transfer potential
ΔpKₐ ≈ 0 (matched)
Unseel.com · Low-Barrier Hydrogen Bonds Unseel.com · Low-Barrier Hydrogen Bonds — Concepts