The Mitsunobu Reaction ·
Invert the Stereocenter
un
seel
.com · R–OH + Nu–H → R–Nu · PPh₃ + DEAD · inversion
Config
(R)
P state
P(III)
Stage
alcohol + reagents assembled
Stereocenter C
Oxygen (of OH)
Phosphorus (PPh₃)
Azo N=N (DEAD)
Nucleophile (Nu⁻)
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.com · Mitsunobu Reaction