Neber Rearrangement · Oxime → Azirine → Amino Ketone
unseel.com · base-driven · via a strained 2H-azirine
Stage oxime OTs
Ring strain low
Step activated oxime ready
Carbon (C)
Nitrogen (N)
Oxygen / OTs leaving group
α-proton (H)
New C–N bond / amino group
Unseel.com · Neber Rearrangement