Oxyanion Hole ·
Chymotrypsin active site
un
seel
.com · two N–H···O bonds cradle the tetrahedral intermediate
N–H···O
—
Å
rate k/k₀
1×
State
—
Ser195 nucleophile / substrate C
Carbonyl O → alkoxide O⁻
Oxyanion-hole N–H donors (Gly193, Ser195)
H-bonds / His57–Asp102 triad
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.com · The Oxyanion Hole