The Ritter Reaction ·
Nitrile + Carbocation → Amide
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.com · R′OH + R-C≡N → R-C(=O)-NH-R′ · Ritter 1948
Stage
alcohol + nitrile
Key ion
—
Step
strong acid loaded
Carbon
Nitrogen (nitrile)
Oxygen
H⁺ / positive charge
New C-N bond
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