Catalytic Triad ·
Ser195–His57–Asp102
un
seel
.com · charge-relay · oxyanion hole · ~10⁹ rate boost
Rate boost
~10⁹×
Ser Oγ pKa
13
Step
—
Ser195 (nucleophile)
His57 (general base)
Asp102 (stabilizer)
Substrate / proton
▶ Play
←
→
🔇 Unmute
Reset
Un
seel
.com · Serine Protease Catalytic Triad