Staudinger Ligation ·
Azide + Phosphine → Amide
un
seel
.com · bioorthogonal · Saxon & Bertozzi 2000
Intermediate
azide + phosphine
N₂ released
0
Step
reactants assembled
Nitrogen (azide N₃)
Phosphorus (P)
Carbonyl / ester trap
New amide bond
Aryl / R fragment
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