Acetaminophen
Toxicity
un
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.com · NAPQI · glutathione · zone-3 necrosis · NAC antidote
NAPQI
0
units
glutathione
100
%
hepatocyte
healthy
phase
—
Safe conjugation (glucuronide · sulfate, ~90%)
CYP2E1 oxidation → NAPQI (~5%)
NAPQI–protein adducts · zone-3 necrosis
Glutathione & N-acetylcysteine rescue
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.com · Acetaminophen Overdose: NAPQI, Glutathione Depletion, and the N-Acetylcysteine Antidote