Acute Tubular
Necrosis
un
seel
.com · ischemic tubule · sloughed cells · muddy brown casts
GFR
100
%
FE
Na
0.8
%
urine Na
12
mEq/L
phase
baseline
state
—
Healthy tubular epithelium + Na pump
ATP-depleted / ischemic injury
Sloughed cells → muddy brown cast
Obstruction · backleak · vasoconstriction
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.com · Acute Tubular Necrosis: Muddy Brown Casts and the Ischemic Tubule