ANCA-Associated Vasculitis — How Neutrophils Attack the Vessel Wall

ANCA Vasculitis

unseel.com · neutrophil · PR3 / MPO · NETosis · vessel wall

neutrophil resting
ANCA hits 0/2
vessel intact

state —

Endothelium / normal structure
Priming: PR3 / MPO on the surface
ANCA IgG · degranulation · NETs
Drug target (rituximab · avacopan)