Extended-Spectrum
Beta-Lactamase
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seel
.com · serine active site · ring cleavage · CTX-M · carbapenem stability
drugs cleaved
0
enzyme
free
target
intact
state
—
Cephalosporin (intact beta-lactam ring)
Ser70 nucleophile / acyl-enzyme
Ring-opened, inactivated drug
Carbapenem trapped / clavulanate block
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.com · Extended-Spectrum Beta-Lactamases (ESBLs): The Enzyme That Cleaves the Cure