Beta-
Thalassemia
un
seel
.com · alpha excess · ineffective erythropoiesis · HbA2 > 3.5%
α:β ratio
1.0
stage
balanced
HbA2
2.5
%
state
—
Alpha-globin chains (unchanged output)
Beta-globin chains (HBB-encoded)
HbA2 / HbF diagnostic rise
Precipitated alpha · dying precursors
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.com · Beta-Thalassemia: When the Globin Chains Don't Balance