Congenital Adrenal
Hyperplasia
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.com · the 21-hydroxylase (CYP21A2) block
17-OHP
80
ng/dL
ACTH
normal
arm
resting
state
—
Steroid precursors (cholesterol → 17-OHP)
Aldosterone & cortisol (blocked arms)
21-hydroxylase block · androgen shunt
ACTH drive → adrenal hyperplasia
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.com · Congenital Adrenal Hyperplasia: The 21-Hydroxylase Block