Local Anesthetic
Sodium Block
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seel
.com · lidocaine · Na
V
channel · use-dependent · action potential
Na⁺ current
100
%
channel
resting
drug
outside
state
—
Na
V
channel & membrane
Neutral base (B) — crosses
Cation (BH⁺) — pore blocker
Action potential fires
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.com · Local Anesthetic Mechanism: How Lidocaine Blocks the Voltage-Gated Sodium Channel