Malignant
Hyperthermia
un
seel
.com · R-Y-R-1 runaway · calcium leak · hypermetabolism · dantrolene
EtCO
2
35
mmHg
temp
37.0
°C
state
safe
phase
—
RYR1 channel & SR (normal)
Cytosolic Ca²⁺ & SERCA burning ATP
Runaway: rigidity · acidosis · heat
Dantrolene — RYR1 blocked
▶ Play
←
→
🔇 Unmute
Reset
Un
seel
.com · Malignant Hyperthermia: The Ryanodine Receptor Runaway