Metastatic
Cascade
un
seel
.com · invasion · intravasation · circulation · extravasation · colonization
step
primary tumor
cells surviving
1,000,000
metastasis
none
state
—
Epithelial cell & basement membrane
EMT / in-transit (E-cadherin lost)
Circulating tumor cell (CTC) & danger
Colonized distant organ (macrometastasis)
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.com · The Metastatic Cascade: How One Cancer Cell Reaches a Distant Organ