Monro-Kellie
Doctrine
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seel
.com · fixed skull · brain + blood + CSF = constant · the pressure–volume curve
ICP
8
mmHg
CPP
82
mmHg
phase
compensating
state
—
Brain parenchyma (~80%, incompressible)
CSF buffer (~10%, ~150 mL) — first to leave
Cerebral blood (~10%, ~150 mL) — second buffer
Mass lesion & the steep pressure–volume curve
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.com · The Monro-Kellie Doctrine: Why the Skull Cannot Forgive a Rising Pressure