MRSA · Altered
PBP2a
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.com · mecA · low-affinity transpeptidase · target bypass
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target
native PBPs
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Native PBP1–4 (beta-lactam target)
PBP2a — mecA-encoded, low affinity
Beta-lactam (D-Ala-D-Ala mimic)
Vancomycin / ceftaroline rescue
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.com · MRSA and the Altered PBP2a: Why Methicillin Stops Working