PD-1 / PD-L1
Checkpoint Blockade
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.com · TCR·MHC · PD-1·PD-L1 brake · SHP-2 · antibody release
T-cell kill
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Signal 1·2: TCR·MHC + CD28·B7
PD-1·PD-L1 inhibitory brake
SHP-2 phosphatase (off switch)
Anti-PD-1 antibody · restored kill
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.com · PD-1 / PD-L1 Checkpoint Blockade: Taking the Brakes Off Killer T Cells