Sickle Cell
Vaso-Occlusion
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.com · one base swap · HbS polymer · sickled cell · microvascular jam
HbS deoxy
0
%
sickled RBCs
0
flow
normal
stage
—
Oxygenated HbS (R-state, soluble)
Deoxy-HbS polymerizing (T-state)
Sickled RBC · occlusion · ischemia
Rescue: HbF · voxelotor · crizanlizumab
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.com · Sickle Cell Vaso-Occlusive Crisis: How One Base Swap Jams the Microcirculation