Tumor
Angiogenesis
un
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.com · hypoxia · HIF-1α · VEGF-A → VEGFR-2 · anti-VEGF
tumor
1.0
mm
VEGF-A
0
new vessels
0
state
—
Tumor cells & hypoxic core
HIF-1α · VEGF-A gradient
Endothelium · VEGFR-2 · tip cell
Bevacizumab · normalized vessel
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.com · Tumor Angiogenesis and Anti-VEGF Therapy: How Cancers Build Their Own Blood Supply