The D-Ala-D-Lac
Escape
un
seel
.com · vancomycin · vanHAX operon · VRE resistance switch
vanco MIC
1
µg/mL
H-bonds
5
/ 5
target
D-Ala-D-Ala
state
—
Lipid II precursor · native D-Ala-D-Ala
Vancomycin (glycopeptide, 5 H-bonds)
vanHAX operon: VanH · VanA · VanX
D-Ala-D-Lac decoy · resistance
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.com · Vancomycin and the D-Ala-D-Lac Escape: The VRE Resistance Switch