The Warburg
Effect
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seel
.com · aerobic glycolysis · GLUT1 · PKM2 · LDHA · lactate
glucose flux
1×
ATP / glucose
36
microenv. pH
7.4
state
—
Glucose & GLUT1 uptake
Glycolysis · PKM2 throttle
Biosynthesis (nucleotides · lipids)
LDHA → lactate · acidosis
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.com · The Warburg Effect: Why Tumors Ferment Glucose Even With Oxygen